Copyright 2002 American Medical Association. All Rights Reserved.
Applicable FARS/DFARS Restrictions Apply to Government Use.2002
A 64-YEAR-OLD woman complained of gradual blurring of vision. Her visual
acuity was 20/60 OU. Biomicroscopic examination demonstrated no anterior segment
abnormalities. She had been taking 20 mg of tamoxifen once daily for 8 years
as prophylaxis for a previously excised breast adenocarcinoma. Funduscopy
revealed refractile crystalline retinal deposits in both maculae (Figure 1, A and B). The appearances were
consistent with a diagnosis of crystalline/tamoxifen retinopathy and treatment
was discontinued. At the 1-year follow-up, the fundal appearance was unchanged
and visual acuity remained at 6/18.
Alwitry A, Gardner I. Tamoxifen Maculopathy. Arch Ophthalmol. 2002;120(10):1402. doi:10.1001/archopht.120.10.1402