In the October 2001 issue of the ARCHIVES, Anteby et al1 described
the ocular abnormalities found in children born after in vitro fertilization
(IVF), including 1 case of unilateral retinoblastoma.
In January 2001, we saw a case of sporadic bilateral retinoblastoma
in a child born after IVF. A 3-year-old girl was referred because of strabismus
of the left eye. There was no family history of ocular disorders. On ocular
examination, visual acuity was 20/20 OD and less than 20/1000 OS. External
examination showed exotropia of the left eye with a small angle of squint.
Anterior segments were normal. On ophthalmoscopic examination, a small retinoblastoma
was found at the nasal periphery of the right eye, and a very large retinoblastoma
was found at the posterior pole of the left eye. Intratumoral calcification
was established with ultrasonography. Histopathologic analysis of the enucleated
left eye confirmed the diagnosis of retinoblastoma. The tumor in the right
eye was treated with a radioactive ruthenium plaque. The tumor scar was flat,
and no new tumors developed in the follow-up period of 10 months. An RB1 gene germline mutation was seen during DNA analysis.
Cruysberg JRM, Moll AC, Imhof SM. Bilateral Sporadic Retinoblastoma in a Child Born After In Vitro Fertilization. Arch Ophthalmol. 2002;120(12):1773. doi: