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December 2002

Bilateral Sporadic Retinoblastoma in a Child Born After In Vitro Fertilization

Arch Ophthalmol. 2002;120(12):1773-1774. doi:

In reply

We thank Cruysberg et al for their interest in our study of children born after IVF. Their report of a sporadic bilateral retinoblastoma in a child born after IVF is fascinating. It may point to the possibility of higher incidence of chromosomal aberrations in children born after IVF. It must be italicasized, however, that neither our study nor the case reported by Cruysberg et al proves whether this is a true phenomenon associated with the IVF process or merely a sporadic occurrence. To shed light on this crucial question, further large-scale prospective studies on the incidence of ocular (and other) abnormalities in IVF offspring should be conducted.

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