A 39-YEAR-OLD man sought treatment for decreased vision in both eyes
of 2 months' duration. Visual acuity was 20/400 OU. Fundus examination showed
optic disc swelling, diffuse hemorrhages, and macular edema (Figure 1). Workup revealed Philadelphia-chromosome–positive
chronic myelogenous leukemia.
Fluorescein angiography demonstrated extensive areas of blockage and
microaneurysms (Figure 2). Three
minutes after the fluorescein injection, active bleeding from the optic disc
neovascularization was noted (Figure 3).
Levy J, Rosenthal G, Klemperer I, Schneck M, Lifshitz T. Active Spontaneous Bleeding From Optic Disc Neovascularization During Fluorescein Angiography. Arch Ophthalmol. 2002;120(12):1766. doi:10.1001/archopht.120.12.1766