In 1931 I published the results of a microscopic study of the incidence of invasion of the optic nerve by retinoblastoma. The report was based on a series of 119 enucleated eyes containing retinoblastoma. In 53 per cent of the eyes the tumor had extended into the optic nerve beyond the lamina cribrosa. . . . The globes from which these statistics were gleaned were enucleated between the years 1878 and 1929, a period of fifty-one years.
. . . In this recent series of 116 eyes with retinoblastoma enucleated since 1934, only 10, or 8 per cent, showed that the operative section was not beyond the tumor extension into the nerve.
A look at the past . . .. Arch Ophthalmol. 1999;117(1):109. doi:10.1001/archopht.117.1.109