CHOCHRJAKOW ligated the ureters in a number of dogs and rabbits and killed some of them after the appearance of uraemic symptoms (second day), and some were allowed to die of uræmia (second to fourth day). In another series he removed the ligature and killed the animals intervals, letting them live from a week to two months. The microscopic preparations of the retina were stained by the Ehrlich-Dogiel methylene-blue method. There were found general edema of the retina, with vacuole formation in and about the ganglion cells, in the nuclear and reticular layers, in the varicose thickening of the nerve fibres and Müllers fibres, as well as swelling of the vascular endothelium and enlargement of the perivascular spaces. All these changes appeared in from 2 to 7 days and disappeared, after restoring the permeability of the ureters, within two months. Similar changes were found in the eyes of persons dead of uræmia. The author believes uræmic blindness with negative ophthalmoscopic findings to be due to the changes he describes in the retina.
A look at the past . . .. Arch Ophthalmol. 1999;117(1):131. doi:10.1001/archopht.117.1.131