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Photo Essay
April 1999

Treatment of Conjunctival Corneal Intraepithelial Neoplasia With Topical Mitomycin C

Arch Ophthalmol. 1999;117(4):544. doi:10.1001/archopht.117.4.544

A 78-YEAR-OLD woman had a lesion that had grown slowly from the temporal perilimbal region, gradually covering the cornea of her left eye (Figure 1). Conjunctival corneal intraepithelial neoplasia was confirmed histopathologically (Figure 2). Topical 0.02% mitomycin C was administered 4 times daily for 14 days. Regression of the tumor was first noted 1 month later, and was accompanied by marked conjunctival hyperemia (Figure 3). Over the next few months the tumor continued to regress. Four months after the commencement of treatment, only a mild corneal opacification and a few large blood vessels remained in the affected region (Figure 4). After 9 months of follow-up, there has been no clinical recurrence of the tumor.

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