Preretinal proliferative membrane formation, which is regulated by various cytokines, is a very important step in the pathogenesis of proliferative diabetic retinopathy.1 In addition to vascular endothelial growth factor, transforming growth factor β2 (TGF-β2) has been shown to play a key role in preretinal membrane formation caused by retinal metabolic abnormalities. Interleukin 6 (IL-6) has also been reported to be involved in the pathogenesis of diabetic retinopathy.2 In this study, to investigate the roles of these cytokines in the pathogenesis of diabetic retinopathy, we searched for systemic and/or ocular factors relevant to TGF-β2 and IL-6 in diabetic eyes.
Ideta R, Yamashita H, Tanaka Y, Kato S, Kitano S, Hori S. Roles of Cytokines in Diabetic Retinopathy. Arch Ophthalmol. 1999;117(5):700-701. doi: