We read with interest the article by White et al1 on the use of polymerase chain reaction (PCR) to detect B- and T-cell gene rearrangements in vitreous specimens from patients with intraocular lymphoma. The diagnosis of intraocular lymphoma remains problematic; false-negative diagnostic vitrectomies for the disease are common. Therefore, new diagnostic approaches for this disorder are needed, and the use of PCR to help confirm the diagnosis should help the clinician.
Whitcup SM, Chan CC, Buggage RR, Nussenblatt RB, Byrnes GA, Rubin BI. Improving the Diagnostic Yield of Vitrectomy for Intraocular Lymphoma. Arch Ophthalmol. 2000;118(3):446. doi: