A 22-MONTH-OLD Laotian girl had declining vision and upbeat nystagmus. The anterior segment was unremarkable on examination, with a clear cornea and lens in both eyes. Funduscopically, bilateral retinoblastoma was diagnosed with subretinal and vitreous seeding (Figure 1).
Results of a systemic workup were normal. The patient received chemotherapy consisting of carboplatin, vincristine sulfate, etoposide, and cyclosporine. Five cycles were administered, each preceded with laser photoablation and/or cryotherapy to the tumor bed. Initially, both eyes responded favorably with a decrease in tumor volume. Findings from B-scan ultrasonography in the left eye demonstrated anterior consolidation of the tumor. In the subretinal space, freely mobile echogenic particles were appreciated (Figure 2).
Gombos DS, Howes E, O'Brien JM. Cholesterosis Following Chemoreduction for Advanced Retinoblastoma. Arch Ophthalmol. 2000;118(3):440-441. doi:10.1001/archopht.118.3.440