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Photo Essay
March 2000

Cholesterosis Following Chemoreduction for Advanced Retinoblastoma

Arch Ophthalmol. 2000;118(3):440-441. doi:10.1001/archopht.118.3.440

A 22-MONTH-OLD Laotian girl had declining vision and upbeat nystagmus. The anterior segment was unremarkable on examination, with a clear cornea and lens in both eyes. Funduscopically, bilateral retinoblastoma was diagnosed with subretinal and vitreous seeding (Figure 1).

Results of a systemic workup were normal. The patient received chemotherapy consisting of carboplatin, vincristine sulfate, etoposide, and cyclosporine. Five cycles were administered, each preceded with laser photoablation and/or cryotherapy to the tumor bed. Initially, both eyes responded favorably with a decrease in tumor volume. Findings from B-scan ultrasonography in the left eye demonstrated anterior consolidation of the tumor. In the subretinal space, freely mobile echogenic particles were appreciated (Figure 2).

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