In their letter, Fine et al1 cite our work as an example of an incorrect conclusion based on an observational study, which the Collaborative Ocular Melanoma Study (COMS) has now corrected:"Observational data may be misleading, as illustrated by the findings of Char et al regarding pre-enucleation radiation therapy for large choroidal melanoma. These authors suggest that pre-enucleation radiation was harmful . . . ."
Char DH, Phillips TL. Controversy Regarding Pre-enucleation Radiation for Uveal Melanoma. Arch Ophthalmol. 2003;121(9):1346. doi:10.1001/archopht.121.9.1346