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April 2004

Special Considerations in the Guidelines for High-Dose Vitamin Supplementationin Patients With Age-Related Macular Degeneration

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Copyright 2004 American Medical Association. All RightsReserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2004

Arch Ophthalmol. 2004;122(4):662. doi:10.1001/archopht.122.4.662-a

Recently, results of an age-related macular degeneration study1 showed a statistically useful diminution in theprogression of age-related macular degeneration in patients using high-dosevitamin supplementation. The study's authors warned of possible adverse effectsof high-dose vitamin supplementation, specifically of beta carotene use inthose who smoke.2,3 Authorsof some recent articles point to possible adverse effects of high doses ofvitamins C and E in women who have heart disease, and some have shown thathigh doses of vitamin A may also have adverse effects.48

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