We read with great interest the article by Paques et al1 aboutthe axon-tracing properties of indocyanine green (ICG). Although the authorsreported "no evidence of neural toxic effects" to the ganglion cells by observingthat "the ganglion cell layer had a normal appearance on histologic sectionsand by epifluorescence examination findings of flat-mounted slides,"1 these observations should be interpreted with cautionbecause of the 3 following reasons.
Rodrigues EB, Meyer CH, Schmidt JC, Kroll P. Toxic Effects of Intravitreal Indocyanine Green on Neuroretinal Cells. Arch Ophthalmol. 2004;122(4):663. doi:10.1001/archopht.122.4.663