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Photo Essay
July 2004

Fundus Autofluorescence and Vitelliform Macular Dystrophy

Arch Ophthalmol. 2004;122(7):1078-1079. doi:10.1001/archopht.122.7.1078

Although vitelliform macular dystrophy causes a deposit of yellowishmaterial in the central macula in young patients, later in the disease itis common to see a partial or almost complete resorption of the yellowishmaterial. The electro-oculogram shows generalized abnormalities, secondaryto mutation of the chloride channel protein, bestrophin.1 Histopathologicanalysis of vitelliform macular dystrophy demonstrates widespread accumulationof lipofuscin in retinal pigment epithelial cells across the fundus.2 Lipofuscin is autofluorescent, and the intensityof fundus autofluorescence parallels the amount and distribution of lipofuscin.

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