We read with interest the intriguing study by Hariprasad et al.1 Fourth-generation fluoroquinolones, such as gatifloxacin,certainly hold great potential in the treatment and prophylaxis of endophthalmitisand other ophthalmic infections. We applaud the authors for their study confirminggatifloxacin's significant penetration into ocular fluids. However, we takeissue with their discussion of moxifloxacin in the "Comment" section.
Fuller JJ, Marcus DM. Vitreous and Aqueous Penetration of Orally Administered Gatifloxacinin Humans. Arch Ophthalmol. 2004;122(9):1408-1409. doi:10.1001/archopht.122.9.1408