A 72-year-old white woman had a 6-month history of keratoconjunctivitisin the left eye. Best-corrected visual acuity was 20/20 OD and counting fingersat 30 cm OS. Examination of the left eye showed multiple, firm, nontendernodules in the upper and lower lids; diffuse papillomatous conjunctiva; anda 360° corneal pannus (Figure 1).The right eye was normal. Lid and conjunctival biopsy specimens were positivefor sebaceous cell carcinoma with extensive pagetoid spread, and the patientunderwent exenteration of the left orbit. Pathological examination of thecornea disclosed pagetoid invasion of the epithelium with underlying inflammatorypannus (Figure 2).
Lin AY, Bhorade AM, Sugar J, Duffy MT, Edward DP. Neoplastic Corneal Pannus in Sebaceous Cell Carcinoma. Arch Ophthalmol. 2004;122(9):1402-1403. doi:10.1001/archopht.122.9.1402