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October 2004

Regarding Chemoreduction for Retinoblastoma and Intracranial Neoplasms

Arch Ophthalmol. 2004;122(10):1570-1571. doi:10.1001/archopht.122.10.1570

We read with interest the recent letter by Moll et al1 regardingretinoblastoma and pineoblastoma. It is gratifying to know that the incidenceof pineal tumors in patients with retinoblastoma has declined in the Netherlandsas well as in our practice.2 Interestingly,we have also observed a disproportionately greater prevalence of inheritedcases despite the relatively small percentage of genetic cases that have apositive family history compared with those that acquire new germ line mutations.3,4 The etiology of what appearsto be an increased susceptibility in familial cases has not been studied,but the answer may shed some light on the timing of one of the events formalignant transformation.

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