A 47-year-old man with AIDS refractory to combination antiretroviral therapy and a history of cytomegalovirus retinitis was referred for exchange of the 8-month-old ganciclovir implant (Vitrasert, Bausch & Lomb, Rochester, NY) in his right eye. His visual acuity was 20/30 OD and 20/20 OS. Funduscopy showed inactive cytomegalovirus in both eyes and a cystlike structure on the apex of the ganciclovir implant in the right eye (Figure 1A). The implant was exchanged and submitted for pathological examination with the cystlike structure attached (Figure 1B). The pathology report showed that the wall of the presumed cyst was composed of inorganic material consistent with the material that surrounds the implant (Figure 2). No inflammation, biological membrane, or cells were identified.
Yenerel NM, Boada R, Clifton B, Zhang J, Saperstein DA. Ganciclovir Implant With Cystlike Abnormality. Arch Ophthalmol. 2005;123(2):282-283. doi:10.1001/archopht.123.2.282