Macular edema is a common cause of visual loss in eyes with central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO). The Central Vein Occlusion Study (CVOS) demonstrated no beneficial effect of grid laser photocoagulation on the visual acuity of patients with macular edema associated with CRVO. The Branch Vein Occlusion Study (BVOS) demonstrated that grid laser photocoagulation for macular edema from perfused BRVO without spontaneous improvement for at least 3 months prior to treatment may, in many cases, be an effective treatment; however, many patients derive limited benefit from laser photocoagulation. Thus, there is a need for additional treatment options for macular edema associated with CRVO and BRVO.
Scott IU, Ip MS. It’s Time for a Clinical Trial to Investigate Intravitreal Triamcinolone for Macular Edema Due to Retinal Vein Occlusion: The SCORE Study. Arch Ophthalmol. 2005;123(4):581-582. doi:10.1001/archopht.123.4.581