A 27-year-old previously healthy man was seen with bilateral floaters, fatigue, and early satiety. His visual acuity was 20/80 OD and 20/70 OS. A clinical examination (Figure 1 and Figure 2) and fluorescein angiography (Figure 3) were performed. Laboratory analysis revealed a white blood cell count of 3.22 × 105/μL, with 12% bands, 14% metamyelocytes, 23% myelocytes, and 9% myeloblasts. Serum glucose and glycosylated hemoglobin levels were within normal limits. There was no evidence of hemoglobinopathy by electrophoresis. A bone marrow biopsy demonstrated the bcr-abl translocation (Figure 4). Chronic myelogenous leukemia was diagnosed, and the patient was given hydroxyurea, allopurinol, and imatinib mesylate (Gleevec). Ophthalmic treatment included panretinal photocoagulation and vitrectomy.
Chronic Myelogenous Leukemia Manifested as Bilateral Proliferative Retinopathy. Arch Ophthalmol. 2005;123(4):576. doi:10.1001/archopht.123.4.576