Klein et al1 compared gradings of lesions associated with age-related macular degeneration from digital and stereoscopic film images. Their data showed that retinal pigment epithelium depigmentation and detachment “were less likely to be graded as present” in digital images compared to film even in dilated pupils.
We share the authors’ views regarding the need to standardize parameters particularly when comparing results from different systems. Standardizing all variables, such as luminance, Kelvin temperature, distance, and angle of view, is critical to set a platform that allows objective comparison between film and digital capture. Not paying attention to these details may bias results.
Khouri AS, Szirth BC, Fechtner RD. Detecting Age-Related Macular Degeneration: Technologies Are Best Compared When Standardized. Arch Ophthalmol. 2005;123(8):1157. doi:10.1001/archopht.123.8.1157-a