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December 2006

Evaluation of the Penetration of Fluoroquinolones in Human Conjunctival Tissue

Arch Ophthalmol. 2006;124(12):1796-1797. doi:10.1001/archopht.124.12.1796-b

Wagner et al1 described the penetration of topical fluoroquinolones into conjunctival tissue and concluded that efficacy relies primarily on structure, mechanism of action, and penetration into the intended site of action, thereby providing “greater efficacy and more expedient elimination of bacteria.”1 They concluded that their study gives a new dual-biopsy technique that may become “a universally approved, standardized means of evaluating topical ocular antibiotics.”1 However, measuring antibiotic concentrations in the conjunctiva is only 1 of many ways to measure the efficacy of topical antibiotics.

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