Glaucoma is the second-leading cause of permanent blindness in developed nations.1 Of the many forms of glaucoma, primary open-angle glaucoma (POAG) is the most common. Primary open-angle glaucoma is a clinically defined condition that is actually a collection of distinct diseases that are all characterized by a progressive optic nerve degeneration associated with insidious loss of visual field. There is a significant genetic contribution to the pathogenesis of POAG, and several loci associated with POAG have been mapped (GLC1A, chromosome 1q24.3-q25.22; GLC1B, chromosome 2cent-q133; GLC1C, chromosome 3q21-244; GLC1D, chromosome 8q235; GLC1E, chromosome 10p15-p146; and GLC1F, chromosome 7q35-q367). Glaucoma genes have been identified at the GLC1A8 and GLC1E9 loci.
Fingert JH, Alward WLM, Kwon YH, Shankar SP, Andorf JL, Mackey DA, Sheffield VC, Stone EM. No Association Between Variations in the WDR36 Gene and Primary Open-Angle Glaucoma. Arch Ophthalmol. 2007;125(3):434-436. doi:10.1001/archopht.125.3.434-b