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Photo Essay
April 2007

Visualization of Lipofuscin Accumulation in Stargardt Macular Dystrophy by High-Resolution Fourier-Domain Optical Coherence Tomography

Arch Ophthalmol. 2007;125(4):575. doi:10.1001/archopht.125.4.575

A 15-year-old patient was diagnosed with Stargardt macular dystrophy based on maculopathy (Figure 1) and abnormal multifocal electroretinographic responses. Retinal images were obtained with high-speed (up to 18 000 A-scans/s; 18 frames/s; 1000 lines/frame), high-resolution (axial ~ 4.5 μm; lateral 10-15 μm) Fourier-domain optical coherence tomography (FDOCT) (constructed at University of California, Davis).1,2 The FDOCT revealed well-demarcated oval to round “bumps” within the retinal pigment epithelial layer extending from subfoveal to 5° extrafoveal (Figure 2A). The outer nuclear layer was not detectable in this area when compared with an age-matched control (Figure 2B).

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