A healthy asymptomatic 6-year-old Indian boy was referred by his optometrist, who noticed a highly unusual fundus appearance on routine examination. His parents were third cousins and had normal ophthalmologic examination results. Best-corrected visual acuity was 20/30 OU. Fundus examination showed multiple white-yellow fish tail–shaped lesions at the level of the retinal pigment epithelium extending to the ora with relative sparing of the foveal region (Figure 1). Autofluorescence imaging using a confocal scanning ophthalmoscope with a 488-nm laser revealed increased autofluorescence of the flecks (Figure 2). Pattern and flash electroretinogram results were normal (Figure 3). Based on clinical examination and electrophysiology results, the diagnosis of benign familial fleck retina was made.
Audo I, Tsang SH, Fu AD, Barnes JA, Holder GE, Moore AT. Autofluorescence Imaging in a Case of Benign Familial Fleck Retina. Arch Ophthalmol. 2007;125(5):714-715. doi:10.1001/archopht.125.5.714