The most essentially different forms are alcohol and tobacco amblyopia on the one hand, and quinine amaurosis on the other.
In the former group there is the clinical picture of a retrobulbar partial optic neuritis with a central scotoma and normal limits of the field. The anatomical changes are limited to the papillomacular bundle of fibers.
The second group is characterized by the existence of vascular changes, diminution of the caliber of the vessels, and necrosis in consequence of ischemia and of the toxic effect on the nerve elements. To this group belong quinine, salicylic acid, male fern, pomegranate root. There is excessive contraction of the visual field, but never multiple peripheral neuritis.
A look at the past. . .. Arch Ophthalmol. 2007;125(6):829. doi:10.1001/archopht.125.6.829