In patients with peripheral ulcerative keratopathy (PUK), concomitant scleritis is highly correlated with systemic disease (72.3% of patients), typically systemic vasculitis, rheumatoid arthritis–related vasculitis, or systemic lupus erythematosus–related vasculitis.1 We describe a patient with necrotizing scleritis and PUK associated with hepatitis C virus (HCV)–related cryoglobulinemia. To our knowledge, this is the first description of this association.
Kedhar SR, Belair M, Jun AS, Sulkowski M, Thorne JE. Scleritis and Peripheral Ulcerative Keratitis With Hepatitis C Virus–Related Cryoglobulinemia. Arch Ophthalmol. 2007;125(6):852-853. doi:10.1001/archopht.125.6.852