Two new pedigrees are presented which lend support to evidence that retinoblastoma is a hereditary form of neoplasia. The first case was that of a girl aged 6 months. The diagnosis was bilateral retinoblastoma. There was minimal intraocular calcification in both eyes. Enucleation of the right eye was advised for pathologic study. The parents refused consent. In a twin sister, seen at the age of 11 months, a bilateral gray reflex had been observed at the age of 6 months. The diagnosis was bilateral retinoblastoma.
A look at the past. . .. Arch Ophthalmol. 2007;125(7):924. doi:10.1001/archopht.125.7.924