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Letters
August 2007

Bradyopsia in an Asian Man

Arch Ophthalmol. 2007;125(8):1138-1140. doi:10.1001/archopht.125.8.1138

Bradyopsia is a rare retinal disorder, first described in 3 unrelated Dutch families.1 Patients with bradyopsia have difficulty tracking moving objects and adapting to sudden changes in luminance levels owing to a defect in the photoreceptor deactivation mechanism within the phototransduction cascades. Homozygous mutations in either the regulator G-protein signaling 9 (RGS9) or RGS9 anchor protein (R9AP) gene that encode the photoreceptor GTPase accelerating protein and its anchor protein, respectively, have been identified in patients with bradyopsia.2 We report a case of bradyopsia in an Asian man with characteristic electrophysiological and genetic findings. This study was approved by the institutional review board of the Singapore Eye Research Institute.

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