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From the Archives of the Archives
September 2007

A look at the past ...

Arch Ophthalmol. 2007;125(9):1274. doi:10.1001/archopht.125.9.1274

In 1940 Feldman, Hinshaw, and Moses reported on the action of a sulfonamide preparation—the sodium salt of p, p′-diaminodiphenylsulfone-N, N′-didextrose sulfonate, known as “promin,” on experimental tuberculosis in the guinea pig. After this preliminary paper, there appeared a series of reports from these investigators on experimental studies relating to the action of various sulfonamide preparations in tuberculosis. Three sulfones were found which had a definitely deterrent action on the progress of established tuberculosis in the experimental guinea pig. These preparations were “promin,” “diasone” (disodium fomaldehyde sulfoxylate diaminodiphenylsulfone) and “promizole” (4, 2′- diaminophenyl-5′-thiazolylsulfone, an isomer of sulfathiazole).

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