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February 01, 2008

Flavoprotein Autofluorescence Detection of Early Ocular Dysfunction

Author Affiliations

Author Affiliations: Department of Ophthalmology, University of Michigan, Ann Arbor.


Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2008

Arch Ophthalmol. 2008;126(2):259-260. doi:10.1001/archophthalmol.2007.44

Metabolic stress occurs at disease onset and causes altered flavoprotein redox activity that increases flavoprotein autofluorescence (FA). Using a new method to measure ocular FA, we studied women with subtle visual dysfunction due to pseudotumor cerebri. Each FA value was greater in the more affected eye of each woman with pseudotumor cerebri, permitting identification of that eye in each case. Flavoprotein autofluorescence values averaged 60% greater in more affected eyes of women with pseudotumor cerebri, but not between eyes of healthy women (control subjects). These results demonstrate the clinical utility of FA and may permit early detection and monitoring of retinal and optic nerve diseases.