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In order to make the iris less sensitive during operation, Rudin injects a small quantity of cocaine in bichloride solution beneath conjunctiva at the upper margin of the cornea. The vesicle there produced is pushed round the cornea with a pledget of cotton. In eleven operations the result was satisfactory in eight, and partially so in two. In one prolonged operation the patient complained of pain. (Koller's method –ED.)
Reference:Arch Ophthalmol. 1897;26:466.
A look at the past . . .. Arch Ophthalmol. 2009;127(1):65. doi:10.1001/archophthalmol.2008.541