ROY W.BECKMD, PhD
To compare clinical outcomes between fellow eyes randomized to femtosecond laser–created flaps (femtosecond group) or mechanical keratome–created flaps (mechanical group) during wavefront-guided laser in situ keratomileusis.
Prospective, randomized, comparative clinical study.
Main Outcome Measures
Efficacy, safety, predictability, stability, changes in corneal optical aberrations, and low-contrast visual acuity before and 1 week and 1, 3, 6, and 12 months after surgery.
Forty-three patients underwent evaluation in this study. One month after surgery, the mean (SD) spherical equivalent was −0.15 (0.30) diopters (D) for the femtosecond group and −0.12 (0.29) D for the mechanical group (differences were not statistically significant). Twelve months after surgery, 39 eyes (98%) in the femtosecond group had uncorrected visual acuity of 20/20 or better compared with 37 (95%) in the mechanical group. The femtosecond group had fewer high-order, spherical, and coma aberrations and more trefoil aberrations than the mechanical group at 1 month (P = .55), 3 months (P = .05), 6 months (P = .33), and 12 months (P = .48) after surgery. At 25% contrast, the femtosecond group had gains at 1 month (P = .01) and 6 months (P = .008) after surgery.
Twelve months after keratomileusis, clinical outcomes were similar for both groups.
Chan A, Ou J, Manche EE. Comparison of the Femtosecond Laser and Mechanical Keratome for Laser In Situ Keratomileusis. Arch Ophthalmol. 2008;126(11):1484-1490. doi:10.1001/archopht.126.11.1484