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From the Archives of the Archives
April 2009

A look at the past . . .

Arch Ophthalmol. 2009;127(4):575. doi:10.1001/archophthalmol.2009.56

Ranvier has made new experiments in regard to the regenerative processes in the corneal epithelium. When a rabbit's cornea is superficially incised, after 24 hours the margins of the wound are found to be gaping and the wedge-shaped defect filled with epithelial cells. Along the edges of the wound, the height of the epithelial layer is diminished one-half. The middle layer, the layer of cuboidal cells, has more or less completely disappeared, and the cylindrical cells have grown broader though their height is less. These changes are not of an irritative nature. Immediately after the injury the cut margin of the epithelial layer is sharp. Four to 6 hours later a cellular process appears at each margin gradually pushing out until the defect is filled with epithelial cells of irregular shape and having large nuclei. These cells have the appearance of being overnourished and this effect is probably attributable to the leucocytes which collect about the wound, their nuclei dividing, their protoplasm breaking down, and nuclei being fully set free for the nutrition of other cells.