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November 9, 2009

Is the Risk of Incidence or Progression of Age-Related Macular Degeneration Increased After Cataract Surgery?

Arch Ophthalmol. 2009;127(11):1528-1529. doi:10.1001/archophthalmol.2009.258

Since the late 1980s, there have been several reports of an association between cataract surgery and age-related macular degeneration (AMD).111 Some report a cross-sectional association1,2,8; some, incidence of AMD after surgery9,10; and yet others report progression to more severe AMD.4,5,10 Still, there are some studies that do not find a significant association after controlling for relevant confounders.12,13 What might explain the disparate results? In my estimation, the diversity of findings in no small part begins with differences in study design.

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