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March 2010

Suppression and Reduction of Corticosteroid-Induced Ocular Hypertension by Anecortave in Sheep

Arch Ophthalmol. 2010;128(3):365-366. doi:10.1001/archophthalmol.2009.410

The article by Candia et al1 represents an important installment in a rapidly evolving story. Topical glucocorticoids administered several times daily can cause a significant increase in intraocular pressure (IOP) in about one-third of the general population, with a rather substantial increase (>15 mm Hg) in about 5%.2,3 Most patients with primary open-angle glaucoma (POAG), their first-order blood relatives, and persons with diabetes mellitus also have a strong ocular hypertensive response to topical glucocorticoids.4,5 There is reasonable evidence that if treated long enough, all humans will exhibit at least some IOP increase.

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