Clinical Trials
December 13, 2010

Randomized Controlled Trial of Patching vs Acupuncture for Anisometropic Amblyopia in Children Aged 7 to 12 Years

Author Affiliations

Author Affiliations: Joint Shantou International Eye Center of Shantou University and Chinese University of Hong Kong, Shantou, China (Drs Zhao, Lam, Wang, Lin, and Zhang), and Department of Ophthalmology and Visual Sciences (Drs Lam, Chen, Zheng, Rao, and Fan) and Institute of Chinese Medicine (Drs Lam and Leung), Chinese University of Hong Kong, Hong Kong, China; Darshan Eye Clinic, Chennai, India (Dr Rao); and Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York (Dr Ritch), and Department of Ophthalmology, New York Medical College, Valhalla (Dr Ritch).




Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2010

Arch Ophthalmol. 2010;128(12):1510-1517. doi:10.1001/archophthalmol.2010.306

Objective  To compare the effectiveness of 2-hour daily patching with the effectiveness of acupuncture in treating anisometropic amblyopia in children aged 7 to 12 years who have worn optimal spectacles for at least 16 weeks.

Methods  In a single-center randomized controlled trial, 88 eligible children with an amblyopic eye who had a best spectacle-corrected visual acuity (BSCVA) of 0.3 to 0.8 logMAR at baseline were randomly assigned to receive 2 hours of patching of the sound eye daily or 5 sessions of acupuncture weekly. All participants in our study received constant optical correction, plus 1 hour of near-vision activities daily, and were followed up at weeks 5, 10, 15, and 25. The main outcome measure was BSCVA in the amblyopic eye at 15 weeks.

Results  The mean BSCVA of the amblyopic eye at 15 weeks improved from baseline by 1.83 and 2.27 lines in the patching and acupuncture groups, respectively. After baseline adjustment, the mean difference of BSCVA between the 2 groups was 0.049 logMAR (95% confidence interval, 0.005-0.092; P = .03), meeting the definition of equivalence (difference within 1 line). The BSCVA had improved by 2 lines or more in 28 (66.7%) and 31 (75.6%) eyes in the patching and acupuncture groups, respectively. Amblyopia was resolved in 7 (16.7%) and 17 (41.5%) eyes in the patching and acupuncture groups, respectively.

Conclusion  Acupuncture produced equivalent treatment effect for anisometropic amblyopia, compared with patching, and was statistically superior. Further studies are warranted to investigate its value in the treatment of amblyopia.

Clinical Relevance  Acupuncture could potentially become an alternative treatment to occlusion therapy for amblyopia.

Trial Registration  Centers for Clinical Trials Registry Identifier: CUHK_CCT00248