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From the Archives of the Archives
March 01, 2008

A look at the past . . .

Author Affiliations

Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2008

Arch Ophthalmol. 2008;126(3):364. doi:10.1001/archopht.126.3.364

Fever therapy—This method of nonspecific treatment was first used in ophthalmology in 1915 by Schmidt, who injected milk to produce fever. Typhoid vaccine was first given intravenously by Kraus and Mazzada, in 1912, and was first used as a nonspecific protein to produce fever several years later, by Miller and Lusk. From 1915 on, the use of fever therapy in ophthalmology became a favored and occasionally an extraordinarily effective manner of treating ocular inflammation.