The problem of the circulation of the aqueous has been recognized for two generations as crucial to an understanding of glaucoma. Clearly, if the aqueous continually enters the interior of the eye in one region, and is continually reabsorbed from the interior of the eye in another anatomic region, then obstruction to the transit of fluid from source to exit, or obstruction to the outflow at the exit, must be considered among the possible causes of a rise of intra-ocular tension. Equally clearly, if no through and through circulation of the aqueous exists, then obstructive theories of glaucoma are untenable. The importance of this issue not merely for the satisfaction of an academic striving for new knowledge, but also for the discovery of a rational mode of therapy for glaucoma, has led to innumerable and extensive investigations in this field.
The volume of literature on this
FRIEDENWALD JS, PIERCE HF. THE CIRCULATION OF THE AQUEOUSI. RATE OF FLOW. Arch Ophthalmol. 1932;7(4):538–557. doi:10.1001/archopht.1932.00820110052005