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Article
February 1933

EFFECT OF REACTION ON OPHTHALMIC SOLUTIONS

Author Affiliations

CHICAGO
From the Department of Ophthalmology, Northwestern University Medical School.

Arch Ophthalmol. 1933;9(2):227-233. doi:10.1001/archopht.1933.00830010240005
Abstract

The effect of drugs introduced into the conjunctival sac in the form of solutions is modified by a number of factors. One of the most important of these is their immediate dilution by tears always present in the sac and by those which rapidly reach it in response to the stimulation afforded by any chemical irritant. A second factor is precipitation of the drug substances present in the tears or conjunctival secretion or its chemical union with such substances. This is especially important when large amounts of highly albuminous secretion are present, as may easily be seen by the white precipitate of silver albuminate which forms when silver nitrate is applied to lids covered with purulent secretion. Such combination, of course, renders most of the drug inactive.

A third factor is that of the reaction of tissues and tears and of the solutions employed. Lipschütz1

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