During the course of a series of experiments to determine the effect of traumatic damage to the lens in rabbits previously treated with lens extract, it was found that although the animals showed high precipitin titers, the amount of intra-ocular inflammation following puncture of the lens, with consequent escape of lens substance, was the same in the treated as in the normal control animals. Several of the rabbits in this experimental group were then tested for anaphylactic reactions by intravenous and intracutaneous injections of lens substance and were found to be nonreactive. An allergic or hypersensitive reaction was not present although the animals had high precipitin titers.
A group of guinea-pigs definitely anaphylactic to lens substance was then subjected to needling operations on the lens. In these animals the intra-ocular reactions following needling seemed to be greater than in the normal animals needled at the same time. These findings sug
BURKY EL. RELATION OF OCULAR SENSITIVITY TO THE ARTHUS PHENOMENON IN THE RABBIT. Arch Ophthalmol. 1933;10(3):368–374. doi:10.1001/archopht.1933.00830040084007