When carcinoma metastasizes to the eye the choroid is usually affected. In 1872, Perls1 reported the first authenticated case of choroidal metastasis, the primary growth having been in the lung. In 1926, Clapp2 collected one hundred and eighteen cases of metastatic carcinoma of the choroid, and since then several other cases have been reported. The intra-ocular metastases usually arise from a carcinomatous breast, lung, uterus or prostate. In some cases the choroidal involvement has extended back into the optic nerve. In the cases reported by Saxer,3 Marchand4 and Cords,5 the meninges of the brain were involved with metastatic growth which extended into the optic nerve sheaths.
In the cases reported by Schöler6 and Uhthoff,7 there were retrobulbar metastases which enveloped the optic nerve.
Metastasis to the optic nerve or to its sheaths is rarely found. A search of the literature
TERRY TL, DUNPHY EB. METASTATIC CARCINOMA IN BOTH OPTIC NERVES SIMULATING RETROBULBAR NEURITIS. Arch Ophthalmol. 1933;10(5):611–614. doi:10.1001/archopht.1933.00830060035004