Various ocular anomalies have been observed in association with oxycephaly. Medullated nerve fibers in the retina have occasionally been reported in cases of oxycephaly, usually, however, without any attempt at correlation. Ratner1 noticed them in two successive cases of oxycephaly and for a time thought that there might be some correlation, but because they were absent in his next six cases of oxycephaly he considered their association merely coincidental. Metzger,2 Kraupa3 and Davis4 each reported a case of oxycephaly in which medullated nerve fibers were present. However, they neither noted nor attempted to establish any correlation.
Medullated nerve fibers, on the other hand, have been reported to occur rather frequently in association with other anomalies and stigmas of degeneration. Kiso5 reported six cases in one family, and in a review of the literature he found mention of four cases in which such fibers were
ABELES MM. MEDULLATED OPTIC NERVE FIBERS ACCOMPANYING OXYCEPHALY AND OTHER CRANIALDEFORMITIES. Arch Ophthalmol. 1936;16(2):188–196. doi:10.1001/archopht.1936.00840200026002