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Article
February 1938

EXPERIMENTAL STUDIES OF OCULAR TUBERCULOSISII. RELATION OF OCULAR ACTIVITY TO OCULAR SENSITIVITY IN THE NORMAL RABBIT INFECTED BY INJECTION OF TUBERCLE BACILLI INTO THE ANTERIOR CHAMBER

Author Affiliations

BALTIMORE
From the Wilmer Ophthalmological Institute of the Johns Hopkins University and Hospital.

Arch Ophthalmol. 1938;19(2):236-244. doi:10.1001/archopht.1938.00850140078009
Abstract

In the first paper of this series,1 attention was directed to certain phases of the general problem of ocular tuberculosis and especially to the rudimentary state of knowledge concerning the relation of cutaneous sensitivity, ocular sensitivity and ocular activity. The results of an investigation on the relation of cutaneous and ocular sensitivity in the normal rabbit infected by systemic injection of human tubercle bacilli were reported. Ocular sensitivity was found to develop synchronously with cutaneous sensitivity, the nondiseased eyes participating in the general development of tissue sensitivity. With minor variations, during the course of this self-limited disease in the rabbit cutaneous and ocular sensitivity ran fairly parallel, reaching their peak from six to eight weeks after systemic inoculation, declining slightly as the animal overcame the infection, but being definitely present for at least nine months after infection, when the last rabbits were tested.

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