In a previous communication1 toxin-producing staphylococci were brought forward as an important cause of chronic catarrhal conjunctivitis. Characteristic of conjunctivitis believed to be staphylococcic is the failure of locally applied antiseptics to heal it or to rid the eye of the offending bacteria. This failure is believed to be related to the predilection of staphylococci for the skin and glands of the margins of the lids ; here the bacteria are protected from the action of antiseptics and are able to reinfect the conjunctiva.
In view of the efficacy of immunization with staphylococcus toxin in protecting rabbits against instillations of toxin which would produce severe conjunctivitis in normal rabbits,1 an attempt has been made to obtain healing in human beings with conjunctivitis by immunization. Although good results with crude toxin have been reported by Burky,2 toxoid was employed in the present study because of its greater safety
THYGESON P. TREATMENT OF STAPHYLOCOCCIC CONJUNCTIVITIS WITH STAPHYLOCOCCUS TOXOIDPRELIMINARY NOTE. Arch Ophthalmol. 1938;20(2):271–273. doi:10.1001/archopht.1938.00850200109004