The lowering of the intraocular pressure by osmotic changes produced by the intravenous injection of hypertonic solutions is well known. Cantonnet1 demonstrated that the ocular volume diminished after the intravenous injection of hypertonic salt solution. Hertel2 showed in animals that the decreased tension produced by injections of hypertonic saline solution was accompanied by a decreased water content of the eyes. The clinical usefulness of the hydrophilic character of hypertonic solutions has found application in various fields of therapy, including that of ophthalmology. However, many ophthalmologists have not taken full advantage of osmotic therapy.
The possession of an additional means of lowering intraocular tension when methods ordinarily used either are contraindicated or are inadequate is a valuable asset. This is particularly apparent when intraocular tension cannot be controlled immediately after an operative procedure on the eye ; in this case inflammation and tenderness are so
BELLOWS J, PUNTENNEY I, COWEN J. USE OF SORBITOL IN GLAUCOMA. Arch Ophthalmol. 1938;20(6):1036–1043. doi:10.1001/archopht.1938.00850240152010