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November 1939


Author Affiliations

From the Wilmer Ophthalmological Institute of the Johns Hopkins University and Hospital.

Arch Ophthalmol. 1939;22(5):849-866. doi:10.1001/archopht.1939.00860110135009

In 1929 Marchesani1 reported the results of experimental work done with a strain of Bacillus subtilis which he had isolated from the sympathogenic eye of a person with mild sympathetic ophthalmia. By repeated intraocular injections of this organism into one eye of a number of rabbits he produced choroiditis in the opposite eye. The lesion consisted of a focal accumulation of mononuclear cells in the choroid. He expressed the belief that the choroiditis thus produced was dependent on paired organ sensitivity of the two eyes which allowed the antigen to localize in the second eye. At a later date2 he repeated these experiments with Bacillus xerosis and Staphylococcus albus and apparently obtained similar results. Iga3 and von Szily4 repeated these experiments with B. subtilis and showed that a similar metastatic choroiditis could be produced by repeated intravenous and intraorbital injections of this organism. They concluded that

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