In the third experiment of this series1 it was noted that when tubercle bacilli were injected into one eye of a normal rabbit the other eye appeared to show a somewhat greater reactivity to purified protein derivative than was manifested by the skin. This introduced the question of organotropism, or selective sensitization of the second eye, a point discussed by many other authors, especially with reference to sympathetic ophthalmia and the frequent bilateral occurrence of clinical ocular tuberculosis.
The previous experiment, in which such a selective sensitivity seemed a possibility, was conducted with normal rabbits under highly artificial conditions; the only tuberculous focus was in the eye, and it resulted from direct inoculation of the anterior chamber with tubercle bacilli. The only indication of selective sensitization of the second eye was found by the comparison of the reactivity to purified protein derivative of the eye and the skin, two
WOODS AC, BURKY EL. EXPERIMENTAL STUDIES OF OCULAR TUBERCULOSISV. THE QUESTION OF ORGANOTROPISM, OR THE SELECTIVE SENSITIZATION OF THE SECOND EYE. Arch Ophthalmol. 1940;23(2):363–368. doi:10.1001/archopht.1940.00860130401008