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Article
March 1940

IS THE ONSET OF INTERSTITIAL KERATITIS RELATED TO RIBOFLAVIN DEFICIENCY?

Author Affiliations

Cleveland.
Cleveland.

Arch Ophthalmol. 1940;23(3):631-632. doi:10.1001/archopht.1940.00860130697024

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Abstract

To the Editor:  —A year ago there appeared, almost simultaneously, an article by Bessey and Wolbach (J. Exper. Med.69: 1 [Jan.] 1939) and one by us (Arch. Ophth.21:315 [Feb.] 1939) relating to observations on the cornea of rats fed diets deficient in riboflavin. The vascularization observed was depicted by each of us, the article by Bessey and Wolbach containing some excellent drawings, and our article, a photograph of a cornea the vessels of which had been injected with india ink. Bessey and Wolbach stated : "Vascularization of the cornea is an early and constant phenomenon in albino rats in riboflavin deficiency. It precedes all other demonstrable lesions of the deficiency." We stated : "From our experience with the diet deficient in riboflavin, the most consistent ocular change was the appearance of corneal vascularization. . . . After riboflavin was added, the most uniform effect was the remission of vascularization."On Dec. 6,

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