The physiology of rod and cone vision has been under investigation for many years, and many significant contributions have been made within the past few years, notably by Hecht and his associates in this country and Lythgoe and his associates in Great Britain. These studies, combined with the increasing knowledge of the biophysics of the eye and the chemistry of the vitamins, enable one to approach the problem of dark adaptation and its clinical significance without the skepticism manifest a few years ago. The greater part of this investigative work has been published in journals not always accessible to ophthalmologists, and frequently an advanced knowledge of physics and chemistry is necessary to interpret the findings. In this paper an attempt is made to review the problem in a brief and simplified manner and to give the present status of dark adaptation and the chemical basis of vision.
McDONALD R. SOME BASIC PRINCIPLES OF DARK ADAPTATION. Arch Ophthalmol. 1940;23(4):841–851. doi:10.1001/archopht.1940.00860130935013